One-Pot Synthesis of Hybrid Multifunctional Silica Nanoparticles with Tunable Coating by Click Chemistry in Reverse W/O Microemulsion

Cédric Tissandier , Noël Diop , Matteo Martini (1) , Stéphane Roux (1) , Olivier Tillement (1) , Thierry Hamaide (2)

1 LPCML - Laboratoire de Physico-Chimie des Matériaux Luminescents
2 IMP-LMPB - Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux

Multifunctional hybrid silica nanoparticles with a fluorescent core and tunable organic or polymeric shell can easily be prepared by a sol-gel process followed by 1,3 dipolar cycloaddition (CuAAC) in the same reverse quaternary W/O microemulsion. Compared to a classical multistep process, this one-pot synthesis reduces greatly the number of purification steps and avoids aggregation phenomena. The confinement of reactants inside the micellar system gives rise to a noticeable increase of the CuAAC reaction rate. In addition, using simultaneously two different substrates for CuAAC on silica allows us to obtain directly multifunctional hybrid nanoparticles displaying a double grafting without any separation or purification steps except the final recovery by centrifugation, which opens the door to a tunable coating of the nanoparticles. Particularly, the hydrophilic-lipophilic balance of the coating can be adjusted by implementing the pertinent MPEG:dodecyl azide ratio. As an application, the great versatility of this strategy has been proved by the one-pot synthesis of fluorescent silica nanoparticles with a PEG coating and encapsulating silver clusters.

Domains: Polymers; Material chemistry

Cédric Tissandier, Noël Diop, Matteo Martini, Stéphane Roux, Olivier Tillement, et al.. One-Pot Synthesis of Hybrid Multifunctional Silica Nanoparticles with Tunable Coating by Click Chemistry in Reverse W/O Microemulsion. Langmuir, 2011, pp.22066823. ⟨10.1021/la203580q⟩. ⟨hal-00650245⟩