Stereoselective synthesis of fluorinated 1,3-cis-diaminocyclopentanes.

Morgane Pasco , Roba Moumné (1, 2) , Thomas Lecourt (3) , Laurent Micouin (3)

1 SSFMB - Synthèse, Structure et Fonction de Molécules Bioactives
2 UPMC - Université Pierre et Marie Curie - Paris 6
3 SSMIP - Synthèse et structure de molécules d'interet pharmacologique

Several fluorinated 1,3-diaminocyclopentanes, previously reported to be useful RNA structural probes, can be prepared in a diastereoselective manner from a single bicyclic hydrazine precursor, in 3 to 9 steps.

Domaines: Chimie organique

Morgane Pasco, Roba Moumné, Thomas Lecourt, Laurent Micouin. Stereoselective synthesis of fluorinated 1,3-cis-diaminocyclopentanes.. Journal of Organic Chemistry, 2011, 76 (12), pp.5137-42. ⟨10.1021/jo2001512⟩. ⟨hal-00649119⟩