The Use of the SAEM Algorithm in MONOLIX Software for Estimation of Population Pharmacokinetic-Pharmacodynamic-Viral Dynamics Parameters of Maraviroc in Asymptomatic HIV Subjects
Résumé
Using simulated viral load data for a given maraviroc monotherapy study design, the feasibility of different algorithms to perform parameter estimation for a pharmacokinetic-pharmacodynamic-viral dynamics (PKPD-VD) model was assessed. The assessed algorithms are the first-order conditional estimation method with interaction (FOCEI) implemented in NONMEM VI and the SAEM algorithm implemented in MONOLIX version 2.4.
Fichier principal
Population_PKPD_Viral_Dynamics_Analysis_of_Maraviroc_Data_Using_MONOLIX_05MAR2010.pdf (695.93 Ko)
Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...