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Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes.

Abstract : As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.
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Submitted on : Thursday, October 20, 2011 - 4:21:51 PM
Last modification on : Thursday, January 11, 2018 - 6:15:02 AM





Maged F Serag, Noritada Kaji, Enrica Venturelli, Yukihiro Okamoto, Kazuyoshi Terasaka, et al.. Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes.. ACS Nano, American Chemical Society, 2011, 5 (11), pp.9264-9270. ⟨10.1021/nn2035654⟩. ⟨hal-00634247⟩



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