Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae.

Grégory Genta-Jouve , Nellie Francezon , Alexandre Puissant , Patrick Auberger , Jean Vacelet , Thierry Pérez , Angelo Fontana , Ali Al Mourabit (1) , Olivier P Thomas

1 ICSN - Institut de Chimie des Substances Naturelles

Citharoxazole (1), a new batzelline derivative featuring a benzoxazole moiety, was isolated from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae Vacelet, 1969, together with the known batzelline C (2). This is the first chemical study of a Mediterranean Latrunculia species and the benzoxazole moiety is unprecedented for this family of marine natural products. The structure was mainly elucidated by the interpretation of NMR spectra and especially HMBC correlations. Copyright © 2011 John Wiley & Sons, Ltd.

Domaines: Chimie organique

Grégory Genta-Jouve, Nellie Francezon, Alexandre Puissant, Patrick Auberger, Jean Vacelet, et al.. Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae.. Magnetic Resonance in Chemistry, 2011, 49 (8), pp.533-536. ⟨10.1002/mrc.2772⟩. ⟨hal-00634141⟩