The role of serotonin in respiratory function and dysfunction.

Gérard Hilaire (1) , Nicolas Voituron (1) , Clément Menuet (1) , Ronaldo M Ichiyama , Hari H Subramanian , Mathias Dutschmann (1)

1 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille

Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.

Domaines: Biochimie [q-bio.BM]

Gérard Hilaire, Nicolas Voituron, Clément Menuet, Ronaldo M Ichiyama, Hari H Subramanian, et al.. The role of serotonin in respiratory function and dysfunction.. Microbes and Infection, 2010, 174 (1-2), pp.76-88. ⟨10.1016/j.resp.2010.08.017⟩. ⟨hal-00625284⟩