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Estimation of the percolation thresholds in ternary lobenzarit disodium–dextran–HPMC hydrophilic matrices tablets: Effects of initial porosity

Abstract : The aim of this work is to estimate the excipient percolation threshold for a new combined matrix native dextran (DT), series B110-1-2 (Mw 2×106): HPMC K4M CR: lobenzarit disodium (LBD) system and demonstrate the advantages of this ternary system with respect to previously reported binary dextran:LBD and HPMC:LBD tablets. The formulations studied were prepared with different amounts of excipient (DT:HPMC, 4:1 (wt/wt) for all tablets and relative polymer/drug particle size of 4.17) in the range of 10–70% (wt/wt). Dissolution studies were carried out using the paddle method (100rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi's models as well as the non-linear regression were employed as empiric methods to study the released data. Values of diffusion exponent 0.588
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Eddy Castellanos Gil, Antonio Iraizoz Colarte, Bernard Bataille, Fabien Brouillet, Isidoro Caraballoc. Estimation of the percolation thresholds in ternary lobenzarit disodium–dextran–HPMC hydrophilic matrices tablets: Effects of initial porosity. European Journal of Pharmaceutical Sciences, Elsevier, 2009, 38 (4), pp.312-319. ⟨10.1016/j.ejps.2009.07.013⟩. ⟨hal-00610199⟩

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