RNA remodeling by hexameric RNA helicases

Abstract : The unwinding of RNA helices and the disruption of RNA-protein complexes are critical steps of cellular metabolism that are carried out by ubiquitous NTP-dependent enzymes named RNA helicases. Here, we review the structures, mechanisms and biochemical properties of two RNA helicases known to adopt a homo-hexameric ring architecture: the P4 packaging motor of bacteriophage.8, a Super-Family 4 helicase and Escherichia coli's transcription termination factor Rho from the Super-Family 5 of helicases. We emphasize the many similarities as well as key differences that characterize the Rho and P4 motor mechanisms and highlight important questions that remain to be addressed.
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Makhlouf Rabhi, Roman Tuma, Marc Boudvillain. RNA remodeling by hexameric RNA helicases. RNA Biology, Taylor & Francis, 2010, 7 (6 - Sp. Iss. SI), pp.655-666. ⟨10.4161/rna.7.6.13570⟩. ⟨hal-00602496⟩



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