Selective suppression of hippocampal ripples impairs spatial memory.

Gabrielle Girardeau (1) , Karim Benchenane (1) , Sidney I. Wiener (1) , György Buzsáki (2) , Michaël Zugaro (1)

1 LPPA - Laboratoire de Physiologie de la Perception et de l'Action
2 CMBN

Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

Domaines: Neurosciences [q-bio.NC]

Gabrielle Girardeau, Karim Benchenane, Sidney I. Wiener, György Buzsáki, Michaël Zugaro. Selective suppression of hippocampal ripples impairs spatial memory.. Nature Neuroscience, 2009, 12 (10), pp.1222-3. ⟨10.1038/nn.2384⟩. ⟨hal-00599372⟩