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Selective suppression of hippocampal ripples impairs spatial memory.

Gabrielle Girardeau 1 Karim Benchenane 1 Sidney Wiener 1 György Buzsáki 2, * Michaël Zugaro 1, *
* Corresponding author
1 LPPA - Laboratoire de Physiologie de la Perception et de l'Action
2 CMBN
Abstract : Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
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https://hal.archives-ouvertes.fr/hal-00599372
Contributor : Michaël Zugaro <>
Submitted on : Thursday, June 9, 2011 - 3:53:48 PM
Last modification on : Wednesday, September 23, 2020 - 4:31:53 AM

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Gabrielle Girardeau, Karim Benchenane, Sidney Wiener, György Buzsáki, Michaël Zugaro. Selective suppression of hippocampal ripples impairs spatial memory.. Nature Neuroscience, Nature Publishing Group, 2009, 12 (10), pp.1222-3. ⟨10.1038/nn.2384⟩. ⟨hal-00599372⟩

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