Tether influence on the binding properties of tRNALys3 ligands designed by a fragment-based approach.

Abstract : A small library of 1,5-triazole derivatives linking a diaminocyclopentadiol and aromatic ketones has been prepared and screened using NMR and fluorescent techniques against tRNA(Lys)(3), the HIV reverse transcription primer. The comparison of their binding properties to those of their 1,4-triazole isomers, previously discovered in a fragment-based approach, outlines the influence of the linker on affinity and binding selectivity in such an approach.
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Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (5), pp.1154-9. 〈10.1039/b921232a〉
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Soumis le : jeudi 26 mai 2011 - 16:41:09
Dernière modification le : jeudi 7 février 2019 - 16:32:37

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Roba Moumné, Valéry Larue, Bili Seijo, Thomas Lecourt, Laurent Micouin, et al.. Tether influence on the binding properties of tRNALys3 ligands designed by a fragment-based approach.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (5), pp.1154-9. 〈10.1039/b921232a〉. 〈hal-00596199〉

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