Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma.

M.-H. Dizier (1) , E. Bouzigon (2) , M. Guilloud-Bataille (1) , C. Bétard (3) , J. Bousquet (4) , D. Charpin (5) , F. Gormand (6) , J. Hochez (2, 7) , J. Just (8) , A. Lemainque (3) , N. Le Moual (9) , R. Matran (10) , F. Neukirch (11) , M.-P. Oryszczyn (9) , E. Paty (12) , I. Pin (13) , D. Vervloet (5) , F. Kauffmann (14) , M. Lathrop (3) , F. Demenais (2) , Isabella Annesi-Maesano (15)

1 Inserm U535 - Génétique épidémiologique et structures des populations humaines
2 INSERM - Institut National de la Santé et de la Recherche Médicale
3 CNG - Centre National de Génotypage
4 Immunopathologie de l'Inflammation
5 Service de Pneumologie-Allergologie [Hôpital de la Timone - APHM]
6 Service de pneumologie [Centre Hospitalier Lyon Sud - HCL]
7 Modélisation mathématique et statistique en biologie et médecine
8 CHU Trousseau [APHP]
9 Epidémiologie et Biostatistique
10 Hôpital Albert Calmette
11 Mécanismes physiopathologiques de l'insuffisance respiratoire et des complications de l'anesthésie
12 Service de Pneumologie et d'Allergologie Pédiatriques
13 Département de médecine aiguë spécialisée
14 GREYC - Groupe de Recherche en Informatique, Image et Instrumentation de Caen
15 ESIM - Epidémiologie des maladies infectieuses et modélisation

In the sample of 295 French EGEA families with at least one asthmatic subject, a genome screen was conducted to identify potential linkage regions specific either to allergic rhinitis (AR) or to asthma as well as those shared by the two diseases. Two binary rhinitis phenotypes based on (1) diagnosis (ARbin1) and (2) symptoms (ARbin2) and a categorical ordered trait (ARcat) were considered. Asthma phenotype was based on answers to a standardized questionnaire plus the presence of bronchial hyper-responsiveness. Linkage analyses were conducted using the maximum likelihood binomial (MLB) method. These analyses provided potential evidence for linkage to three regions in the whole sample: 1p31 for the phenotype defined by ARbin2 plus asthma (P=0.00016), 2q32 for ARbin2 (P=0.00016) and 3p24-p14 for ARcat (P=0.001). Two other regions were detected in the subset of 185 families with at most one asthmatic sib: 9p22 and 9q22-q34 for ARbin1 (P=0.001 and 0.0007, respectively). No region showed evidence for linkage to asthma without being also linked to AR. While 1p31 may contain a genetic determinant common to asthma and AR, 2q32, 3p24-p14, 9p22 and 9q22-q34 are more likely to harbor genetic factors specific to AR.

Domaines: Santé publique et épidémiologie

M.-H. Dizier, E. Bouzigon, M. Guilloud-Bataille, C. Bétard, J. Bousquet, et al.. Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma.. Genes and Immunity, 2005, 6 (2), pp.95-102. ⟨10.1038/sj.gene.6364163⟩. ⟨hal-00595641⟩