Long-Range Protein Coupling Mediated by Critical Low-Energy Modes of Tubular Lipid Membranes

Sylvain Monnier (1, 2) , S.B. Rochal (3) , A. Parmeggiani (2) , Vladimir Lorman (1)

1 LPTA - Laboratoire de Physique Théorique et Astroparticules
2 DMIM - Dynamique moléculaire des interactions membranaires
3 SFEDU - Southern Federal University [Rostov-on-Don]

We develop a theory of a resonant effect in protein-membrane coupling taking place in the vicinity of instabilities in tubular lipid membranes (TLMs) under longitudinal force and pressure difference constraints. Two critical low-energy modes defining the stability domain boundaries are found. We show that these modes mediate long-range TLM-protein coupling and interactions between absorbed proteins. Besides, TLM mechanical instabilities strongly influence protein desorption and protein cluster nucleation on TLMs. Model predictions can be tested over a large spectrum of mechanochemical conditions

Domaines: Biologie moléculaire

Sylvain Monnier, S.B. Rochal, A. Parmeggiani, Vladimir Lorman. Long-Range Protein Coupling Mediated by Critical Low-Energy Modes of Tubular Lipid Membranes. Physical Review Letters, 2010, 105 (Issue 2), pp.028102. ⟨10.1103/PhysRevLett.105.028102⟩. ⟨hal-00590709⟩