Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.

Ruth Mcnamara (1, 2) , Jeffrey W Dalley (1, 2, 3) , Trevor W Robbins (1, 2) , Barry J Everitt (1, 2) , David Belin (4)

1 Department of Experimental Psychology
2 Behavioural and Clinical Neuroscience Institute
3 Department of Psychiatry
4 IPBC - Institut de physiologie et biologie cellulaires

Although high impulsivity on the 5-CSRTT has been shown to predict loss of control over cocaine intake, this does not generalize to a loss of control over heroin self-administration. These findings suggest important distinctions in vulnerability mechanisms underlying cocaine and heroin addiction with trait-like impulsivity playing a role in stimulant but not opiate addiction.

Domaines: Psychologie et comportements

Ruth Mcnamara, Jeffrey W Dalley, Trevor W Robbins, Barry J Everitt, David Belin. Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.. Psychopharmacology, 2010, 212 (4), pp.453-64. ⟨10.1007/s00213-010-1974-9⟩. ⟨hal-00583088⟩