Efficient immobilization of fructose-6-phosphate aldolase in layered double hydroxide: improved stereoselective synthesis of sugar analogues

Christine Guérard-Hélaine (1) , Bertrand Legeret (1) , Carlos Fernandes (1) , Vanessa Prevot (2) , Claude Forano (2) , Marielle Lemaire (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique
2 LMI - Laboratoire des Matériaux Inorganiques

Fructose-6-phosphate aldolase immobilized on layered double hydroxide (FSA@LDH) has been characterized and evaluated as a biocatalyst in aldol reactions. The versatile FSA@LDH showed a comparable activity to the free FSA and can be reused several times without a notable loss of activity

Christine Guérard-Hélaine, Bertrand Legeret, Carlos Fernandes, Vanessa Prevot, Claude Forano, et al.. Efficient immobilization of fructose-6-phosphate aldolase in layered double hydroxide: improved stereoselective synthesis of sugar analogues. New J. Chem., 2011, 35, pp.776-779. ⟨hal-00582409⟩