Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus.

Casandra C van Bavel (1) , Jürgen W Dieker (1) , Yvet Kroeze (1) , Wim P Tamboer (1) , Reinhard Voll (2) , Sylviane Muller (3) , Jo H Berden (1) , Johan van Der Vlag (1)

1 Department of Nephrology
2 Nikolaus-Fiebiger Centre of Molecular Medicine
3 ICT - Immunologie et chimie thérapeutiques

In addition to previously identified acetylation of histone H4, H2A and H2B, this study shows that trimethylation of histone H3 on lysine 27 is induced by apoptosis and associated with autoimmunity in SLE. This finding is important for understanding the autoimmune response in SLE and for the development of translational strategies.

Domaines: Biologie moléculaire; Immunologie

Casandra C van Bavel, Jürgen W Dieker, Yvet Kroeze, Wim P Tamboer, Reinhard Voll, et al.. Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus.. Annals of the Rheumatic Diseases, 2011, 70 (1), pp.201-7. ⟨10.1136/ard.2010.129320⟩. ⟨hal-00553595⟩