Engineering the chloroplast targeted malarial vaccine antigens in chlamydomonas starch granules.

David Dauvillée (1) , Stéphane Delhaye (1, 2) , Sébastien Gruyer (1) , Christian Slomianny (3) , Samuel E Moretz (4) , Christophe d'Hulst (1) , Carole A Long (4) , Steven G Ball (1) , Stanislas Tomavo (1, 2)

1 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
2 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
3 Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
4 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease

This novel system paves the way for the production of clinically relevant plasmodial antigens as algal starch-based particles designated herein as amylosomes, demonstrating that efficient production of edible vaccines can be genetically produced in Chlamydomonas.

Domaines: Biochimie [q-bio.BM]

David Dauvillée, Stéphane Delhaye, Sébastien Gruyer, Christian Slomianny, Samuel E Moretz, et al.. Engineering the chloroplast targeted malarial vaccine antigens in chlamydomonas starch granules.. PLoS ONE, 2010, 5 (12), pp.e15424. ⟨10.1371/journal.pone.0015424⟩. ⟨hal-00550569⟩