Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature.

Renaud Sabatier (1) , Corinne Bouvier (2) , Gonzague de Pinieux (3) , Anthony Sarran (1) , Isabelle Brenot-Rossi (1) , Florence Pedeutour (4) , Bruno Chetaille (1) , Patrice Viens (5, 6) , Pierre-Jean Weiller (2) , François Bertucci (1)

1 IPC - Institut Paoli-Calmettes
2 TIMONE - Hôpital de la Timone [CHU - APHM]
3 Hôpital Trousseau
4 IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer
5 SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
6 CRCM / U891 Inserm - Centre de Recherche en Cancérologie de Marseille

Background: Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare. Case presentation: We present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man. Because of initial misdiagnosis and patient's refusal of surgery, the diagnosis was done after a 4-year history of a slowly growing mass in soft tissues, leading to a huge (30-cm diameter) calcified mass locally extended over the left chest wall. Final diagnosis was helped by molecular analysis of MDM2 and CDK4 oncogenes. Unfortunately, at this time, no surgical treatment was possible due to loco-regional extension, and despite chemotherapy, the patient died one year after diagnosis, five years after the first symptoms. Conclusion: We describe the clinical, radiological and bio-pathological features of this unique case, and review the literature concerning low-grade ESOS. Our case highlights the diagnostic difficulties for such very rare tumours and the interest of molecular analysis in ambiguous cases.

Domaines: Cancer; Rhumatologie et système ostéo-articulaire

Renaud Sabatier, Corinne Bouvier, Gonzague de Pinieux, Anthony Sarran, Isabelle Brenot-Rossi, et al.. Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature.. BMC Cancer, 2010, 10, pp.645. ⟨10.1186/1471-2407-10-645⟩. ⟨hal-00546735⟩