Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence.

Ahmet Ayav (1) , Adeline Germain (1) , Frédéric Marchal (2, 3) , Ioannis Tierris (1) , Valérie M. Laurent (1) , Christophe Bazin (1) , Yufeng Yuan (1) , Laurence Robert (1) , Laurent Brunaud (1) , Laurent Bresler (1)

1 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
2 CRAN - Centre de Recherche en Automatique de Nancy
3 CAV - Centre Alexis Vautrin

BACKGROUND: Radiofrequency ablation (RFA) of liver tumors is associated with a risk of incomplete ablation or local recurrence. METHODS: One hundred sixty-eight patients with 311 unresectable liver tumors were included. Effects of different variables on incomplete ablation and local recurrence were analyzed. RESULTS: There were 132 hepatocellular carcinomas and 179 liver metastases. Tumor size was 24 (+/-13) mm. Two hundred twenty-six tumors were treated percutaneously, and 85 through open approach (associated with liver resection in 42 cases). There was no mortality. Major morbidity rate was 7%. Incomplete ablation and local recurrence rates were 14% and 18.6%. Follow-up was 29 months. On multivariate analysis, factors associated with incomplete ablation were tumor size (>30 mm vs 30 mm vs 65 years vs 30 mm. When tumor ablation is completely achieved, the main factor associated with local recurrence is tumor size >30 mm.

Mots clés: Liver tumor; Radiofrequency ablation; Incomplete ablation; Local recurrence

Domaines: Biophysique

Ahmet Ayav, Adeline Germain, Frédéric Marchal, Ioannis Tierris, Valérie M. Laurent, et al.. Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence.. American Journal of Surgery, 2010, 200 (4), pp.435-439. ⟨10.1016/j.amjsurg.2009.11.009⟩. ⟨hal-00521310⟩