Analysis of c-Met kinase domain complexes: a new specific catalytic site receptor model for defining binding modes of ATP-competitive ligands

Y. Asses , Vincent Leroux , S. Tairi-Kellou , R. Dono (1) , F. Maina (1) , Bernard Maigret

1 IBDM - Institut de Biologie du Développement de Marseille

Mots clés: Adenosine Triphosphate/*chemistry/metabolism; Allosteric Regulation; Amino Acid Sequence; Antineoplastic Agents/chemistry/pharmacology; Catalytic Domain; Computer Simulation; Crystallography; X-Ray; Drug Design; Ligands; Molecular Sequence Data; Protein Binding; Protein Kinase Inhibitors/chemistry/pharmacology; Protein Structure; Secondary; Proto-Oncogene Proteins c-met/*chemistry/metabolism

Domaines: Biologie cellulaire

Y. Asses, Vincent Leroux, S. Tairi-Kellou, R. Dono, F. Maina, et al.. Analysis of c-Met kinase domain complexes: a new specific catalytic site receptor model for defining binding modes of ATP-competitive ligands. Chemical Biology and Drug Design, 2009, 74 (6), pp.560-70. ⟨10.1111/j.1747-0285.2009.00895.x⟩. ⟨hal-00507523⟩