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Development of monocytes, macrophages, and dendritic cells.

Abstract : Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.
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Contributor : Marie Laure Haon Connect in order to contact the contributor
Submitted on : Friday, July 16, 2010 - 11:36:18 AM
Last modification on : Wednesday, November 18, 2020 - 9:34:03 AM

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Frederic Geissmann, Markus G Manz, Steffen Jung, Michael Sieweke, Miriam Merad, et al.. Development of monocytes, macrophages, and dendritic cells.. Science, American Association for the Advancement of Science, 2010, 327 (5966), pp.656-61. ⟨10.1126/science.1178331⟩. ⟨hal-00502972⟩



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