Facile synthesis of simple mono-alkyl phosphates from phosphoric acid and alcohols

Cyril Dueymes (1) , Celine Pirat , Robert Pascal (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Simple aliphatic alcohols can be selectively converted into mono-alkyl phosphate esters at the laboratory scale using the acetic anhydride-mediated activation of inorganic phosphate. (C) 2008 Elsevier Ltd. All rights reserved.

Mots clés: phosphorylation; mono-alkyl phosphate; acetic anhydride

Domaines: Chimie organique

Cyril Dueymes, Celine Pirat, Robert Pascal. Facile synthesis of simple mono-alkyl phosphates from phosphoric acid and alcohols. Tetrahedron Letters, 2008, 49, pp.5300-5301. ⟨10.1016/j.tetlet.2008.06.083⟩. ⟨hal-00493433⟩