Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under reductant-free conditions.

Marie-Laure Teyssot (1) , Lionel Nauton (1) , Jean-Louis Canet (1) , Federico Cisnetti (1) , Aurélien Chevry (1) , Arnaud Gautier (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique

Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) has been successfully conducted under reductant-free conditions. The catalytic system consisted of a combination of a copper(I)-N-heterocyclic carbene complex and aromatic N-donors. The catalyst is stable and can be stored, thus rendering the reaction valuable for routine use

Mots clés: Click chemistry; CuAAC; ­Heterocycles; Carbenes; Copper

Domaines: Chimie

Marie-Laure Teyssot, Lionel Nauton, Jean-Louis Canet, Federico Cisnetti, Aurélien Chevry, et al.. Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under reductant-free conditions.. European Journal of Organic Chemistry, 2010, pp.3507-3515. ⟨10.1002/ejoc.201000046⟩. ⟨hal-00492922⟩