Merkel cell polyomavirus strains in patients with merkel cell carcinoma

Antoine Touzé (1, 2, 3) , Julien Gaitan (4) , Annabel Maruani (5) , Emmanuelle Le Bidre (2) , Angélique Doussinaud , Christine E. Clavel (6) , Anne Durlach (7) , François Aubin (8, 9) , Serge Guyétant (4) , Gérard Lorette (2) , Pierre Coursaget (1, 2, 3)

1 U618
2 Université Francois Rabelais [Tours]
3 ATI - Agents transmissibles et infectiologie
4 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
5 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
6 PERPMP - Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903
7 Hôpital universitaire Robert Debré [Reims]
8 CEF2P / CARCINO - Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181)
9 Département de dermatologie

We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.

Domaines: Cancer

Antoine Touzé, Julien Gaitan, Annabel Maruani, Emmanuelle Le Bidre, Angélique Doussinaud, et al.. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerging Infectious Diseases, 2009, 15 (6), pp.960-962. ⟨10.3201/eid1506.081463⟩. ⟨hal-00492511⟩