Nanoscale analysis of supported lipid bilayers using atomic force microscopy.

K. El Kirat (1) , S. Morandat (2) , Y.F. Dufrêne (3)

1 BMBI - Biomécanique et Bioingénierie
2 GEC - Génie Enzymatique et Cellulaire
3 UCL - Unité de Chimie des Interfaces

During the past 15years, atomic force microscopy (AFM) has opened new opportunities for imaging supported lipid bilayers (SLBs) on the nanoscale. AFM offers a means to visualize the nanoscale structure of SLBs in physiological conditions. A unique feature of AFM is its ability to monitor dynamic events, like bilayer alteration, remodelling or digestion, upon incubation with various external agents such as drugs, detergents, proteins, peptides, nanoparticles, and solvents. Here, we survey recent progress made in the area.

Domaines: Biochimie, Biologie Moléculaire; Biophysique

K. El Kirat, S. Morandat, Y.F. Dufrêne. Nanoscale analysis of supported lipid bilayers using atomic force microscopy.. Biochimica et Biophysica Acta:Biomembranes, 2010, 1798 (4), pp.750-765. ⟨10.1016/j.bbamem.2009.07.026⟩. ⟨hal-00468464⟩