Characterization of the CtsR stress response regulon in Lactobacillus plantarum.

Daniela Fiocco (1) , Vittorio Capozzi (1) , Michael J. Collins (2) , Anna Gallone (1) , Pascal Hols (3) , Jean Guzzo (4) , Stephanie Weidmann (4) , Aurélie Rieu (4) , Tarek Msadek (2) , Giuseppe Spano (1)

1 Unifg - Università degli Studi di Foggia = University of Foggia
2 Biologie des Bactéries Pathogènes à Gram-positif
3 UCL - Université Catholique de Louvain = Catholic University of Louvain
4 REVV - Laboratoire de Recherche en Vigne et Vin

Lactobacillus plantarum ctsR was characterized. ctsR was found to be cotranscribed with clpC and induced in response to various abiotic stresses. ctsR deletion conferred a heat-sensitive phenotype with peculiar cell morphological features. The transcriptional pattern of putative CtsR regulon genes was examined in the Delta ctsR mutant. Direct CtsR-dependent regulation was demonstrated by DNA-binding assays using recombinant CtsR and the promoters of the ctsR-clpC operon and hsp1.

Domaines: Bactériologie

Daniela Fiocco, Vittorio Capozzi, Michael J. Collins, Anna Gallone, Pascal Hols, et al.. Characterization of the CtsR stress response regulon in Lactobacillus plantarum.. Journal of Bacteriology, 2010, 192 (3), pp.896-900. ⟨10.1128/JB.01122-09⟩. ⟨hal-00450675⟩