Silica-supported L-proline organocatalysts for asymmetric aldolisation

Alexandra Zamboulis (1) , Nicolas J. Rahier (1) , Matthias Gehringer (1) , Xavier Cattoën (1) , Gilles Niel (1) , Catherine Bied (1) , Joël J.E. Moreau (1) , Michel Wong Chi Man (1)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

New heterogenised silica-based organocatalysts have been prepared via the sol–gel process from two silylated derivatives of L-proline, featuring either a carbamate or an ether linker. Co-gelification with variable amounts of TEOS was performed with and without porogen to yield high surface area solids. These materials were evaluated as heterogeneous phase organocatalysts for the asymmetric aldol reaction of pnitrobenzaldehyde with acetone.

Domaines: Chimie organique

Alexandra Zamboulis, Nicolas J. Rahier, Matthias Gehringer, Xavier Cattoën, Gilles Niel, et al.. Silica-supported L-proline organocatalysts for asymmetric aldolisation. Tetrahedron: Asymmetry, 2009, 20, pp.2880-2885. ⟨10.1016/j.tetasy.2009.11.024⟩. ⟨hal-00449014⟩