Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.

P. Y. Benhamou , L. Milliat-Guittard , A. Wojtusciszyn (1) , L. Kessler , C. Toso , R. Baertschiger , I. Debaty , L. Badet , A. Penfornis , C. Thivolet , E. Renard (1, 2) , F. Bayle , Pierre Morel , E. Morelon , C. Colin , T. Berney , Non Renseigné

1 CPID - Centre de pharmacologie et innovation dans le diabète
2 Hôpital Arnaud de Villeneuve [CHRU Montpellier]

BACKGROUND: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. METHODS: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). RESULTS: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. CONCLUSION: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.

Domaines: Endocrinologie et métabolisme

P. Y. Benhamou, L. Milliat-Guittard, A. Wojtusciszyn, L. Kessler, C. Toso, et al.. Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.. Diabetic Medicine, 2009, 26 (6), pp.617-21. ⟨10.1111/j.1464-5491.2009.02731.x⟩. ⟨hal-00438784⟩