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Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.

Abstract : BACKGROUND: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. METHODS: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). RESULTS: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. CONCLUSION: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
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Contributor : Anne Wojtusciszyn Connect in order to contact the contributor
Submitted on : Friday, December 4, 2009 - 4:17:43 PM
Last modification on : Monday, August 30, 2021 - 12:06:01 PM

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P. Y. Benhamou, L. Milliat-Guittard, A. Wojtusciszyn, L. Kessler, C. Toso, et al.. Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.. Diabetic Medicine, Wiley, 2009, 26 (6), pp.617-21. ⟨10.1111/j.1464-5491.2009.02731.x⟩. ⟨hal-00438784⟩



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