Well-differentiated and dedifferentiated liposarcomas.

Jean-Michel Coindre (1) , Florence Pédeutour (2) , Alain Aurias (3)

1 Plateforme de génétique moléculaire des cancers d'Aquitaine
2 IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer
3 U830 - Unité de génétique et biologie des cancers

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

Domaines: Biologie du développement

Jean-Michel Coindre, Florence Pédeutour, Alain Aurias. Well-differentiated and dedifferentiated liposarcomas.. American Journal of Human Genetics, 2010, 456 (2), pp.167-179. ⟨10.1007/s00428-009-0815-x⟩. ⟨hal-00437654⟩