New access to trisubstituted 3-pyrrolines under phosphine catalysis.

Marie Schuler (1) , Deepti Duvvuru (1) , Pascal Retailleau (1) , Jean-François Betzer (1) , Angela Marinetti (1)

1 ICSN - Institut de Chimie des Substances Naturelles

Conjugated dienes, properly activated by electron-withdrawing groups on both ends, are shown to be suitable substrates for phosphine-promoted organocatalytic processes. Their reactions with imines, under phosphine catalysis, afford a new and efficient synthetic approach to functionalized 3-pyrrolines.

Domaines: Biologie cellulaire

Marie Schuler, Deepti Duvvuru, Pascal Retailleau, Jean-François Betzer, Angela Marinetti. New access to trisubstituted 3-pyrrolines under phosphine catalysis.. Organic Letters, 2009, 11 (19), pp.4406-9. ⟨10.1021/ol901758k⟩. ⟨hal-00431900⟩