Environmentally friendly Pd/Cu -catalysed C3-alkenylation of free NH-indoles

L. Djakovitch (1) , P. Rouge

1 IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon

A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70 degrees C, air), substituted indoles are fully (58-82% isolated yields) and selectively (75-100% selectivity) converted to the expected 2-substituted-3-vinylindoles. (C) 2008 Elsevier B.V. All rights reserved.

Domaines: Catalyse

L. Djakovitch, P. Rouge. Environmentally friendly Pd/Cu -catalysed C3-alkenylation of free NH-indoles. Catalysis Today, 2009, 140 (1-2), pp.90-99. ⟨10.1016/j.cattod.2008.07.013⟩. ⟨hal-00431153⟩