Novel Amphiphilic Degradable Poly(-caprolactone)-graft-poly(4-vinyl pyridine), Poly(-caprolactone)-graft-poly(dimethylaminoethyl methacrylate) and Water-Soluble Derivatives

Benjamin Nottelet (1) , Michel Vert (1) , Jean Coudane (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

New amphiphilic graft copolymers that have a poly(-caprolactone) (PCL) biodegradable hydrophobic backbone and poly(4-vinylpyridine) (P4VP) or poly(2-(N,N-dimethylamino)ethyl methacrylate) (PDMAEMA) hydrophilic side chains have been prepared by anionic polymerization of the corresponding 4VP and DMAEMA monomers using a PCL-based macropolycarbanion as initiator. The water solubility of these amphiphilic copolymers is improved by quaternization, which leads to fully water-soluble cationic copolymers that give micellar aggregates in deionized water with diameters ranging from 65 to 125 nm. In addition, to improve the hydrophilicity of PCL-g-P4VP, grafting of poly(ethylene glycol) (PEG) segments has been carried out to give a water-soluble double grafted PCL-g-(P4VP;PEG) terpolymer.

Domaines: Polymères

Benjamin Nottelet, Michel Vert, Jean Coudane. Novel Amphiphilic Degradable Poly(-caprolactone)-graft-poly(4-vinyl pyridine), Poly(-caprolactone)-graft-poly(dimethylaminoethyl methacrylate) and Water-Soluble Derivatives. Macromolecular Rapid Communications, 2008, 29 (9), pp.743-750. ⟨10.1002/marc.200800037⟩. ⟨hal-00416815⟩