A Large-Scale Low-Cost Preparation of N-Benzylhydroxylamine Hydrochloride

T .B. Nguyen (1) , Arnaud Martel (1) , Robert Dhal (1) , Gilles Dujardin (1)

1 UCO2M - Unité de chimie organique moléculaire et macromoléculaire

A high-yielding, practical two-step procedure for the preparation of N-benzylhydroxylamine starting from dibenzylamine is described­. As specified in the detailed protocol, the reaction can be conveniently carried out on a > 0.5 mol laboratory scale.

Mots clés: N-benzylhydroxylamine; N-benzylnitrones; 3-dipolar cycloaddition; secondary amine oxidation; nitrone hydrolysis

Domaines: Chimie organique

T .B. Nguyen, Arnaud Martel, Robert Dhal, Gilles Dujardin. A Large-Scale Low-Cost Preparation of N-Benzylhydroxylamine Hydrochloride. Synthesis: Journal of Synthetic Organic Chemistry, 2009, 18, pp.3174-3176. ⟨10.1055/s-0029-1216932⟩. ⟨hal-00414352⟩