System identification of tumor growth described by a mixed effects model

Abstract : System identification of treated tumor growth is addressed in this paper. Three main difficulties are examined: (i) the determination of a suited dynamical model structure (modeling problem), (ii) the inter-individual variability of the therapeutic responses (population identification problem or longitudinal data analysis) and (iii) the effects of some categorical factors on the model parameters. To solve these problems, a mixed effect model of tumor growth, a two step identification approach and an estimation algorithm based on expectation maximization, are proposed and applied to in vivo data. A double effect of treatments on the tumor volume responses is pointed out.
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Submitted on : Sunday, November 29, 2009 - 6:17:53 PM
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Thierry Bastogne, Adeline Samson, Sophie Mézières-Wantz, Pierre Vallois, Sophie Pinel, et al.. System identification of tumor growth described by a mixed effects model. 15th IFAC Symposium on System Identification, SYSID 2009, Jul 2009, Saint-Malo, France. pp.CDROM. ⟨hal-00412535⟩



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