Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles

Lenaic Lartigue (1) , K. Oumzil (2) , Yannick Guari (1) , Joulia Larionova (3) , Christian Guérin (1) , Jean-Louis Montero (2) , Véronique Barragan-Montero (2) , Claudio Sangregorio (4) , Andrea Caneschi (5) , C. Innocenti , T. Kalaivani , P. Arosio , Allessandro Lascialfari (6)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 CMOS - Chimie moléculaire et organisation du solide
4 Dipartimento di Chimica
5 LAMM - Dipartimento di Chimica & UdR INSTM
6 Istituto di Fisiologia Generale e Chimica Biologica

Water-soluble biocompatible rhamnose-coated Fe(3)O(4) nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.

Domaines: Chimie de coordination

Lenaic Lartigue, K. Oumzil, Yannick Guari, Joulia Larionova, Christian Guérin, et al.. Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles. Organic Letters, 2009, 11, pp.2992-2995. ⟨10.1021/ol900949y⟩. ⟨hal-00403246⟩