Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines

F. Rondu , G. Le Bihan , X. Wang (1) , A. Lamouri , E. Touboul , G. Dive (2) , T. Bellahsene , B. Pfeiffer (3) , P. Renard (3) , B. Guardiola-Lemaitre , D. Manechez , Luc Pénicaud (4) , Alain Ktorza (5) , J. J. Godfroid

1 CAN-FOR
2 CIP - Centre d’Ingénierie des Protéines [Université de Liège] = Centre for Protein Engineering [University of Liège]
3 INSTITUT DE RECHERCHES SERVIER - Institut de recherches Servier
4 LMPM - Métabolisme Plasticité et Mitochondrie [lié à l'ex IFR 31]
5 LPN - Laboratoire de physiopathologie de la nutrition

Domaines: Alimentation et Nutrition

F. Rondu, G. Le Bihan, X. Wang, A. Lamouri, E. Touboul, et al.. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines. Journal of Medicinal Chemistry, 1997, 40, pp.3793-3803. ⟨hal-00399364⟩