mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice.

E. Pecchi (1) , M. Dallaporta (1) , A. Jean (1) , S. Thirion (1, 2) , J. D. Troadec (1)

1 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
2 ICN - Interactions cellulaires neuroendocriniennes

Anorexia-cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia-cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.

Domaines: Biochimie [q-bio.BM]

E. Pecchi, M. Dallaporta, A. Jean, S. Thirion, J. D. Troadec. mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice.. Journal of Neuroimmunology, 2008, 199 (1-2), pp.104-14. ⟨10.1016/j.jneuroim.2008.05.012⟩. ⟨hal-00398610⟩