Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer.

Marion Gabant (1) , Isabelle Schmitz-Afonso (1) , Jean-François Gallard (1) , Jean-Louis Menou , Dominique Laurent , Cécile Debitus (1) , Ali Al-Mourabit (1)

1 ICSN - Institut de Chimie des Substances Naturelles

Three new pregnanes, ptilosteroid A (1), ptilosteroid B (2), and ptilosteroid C (3), and two new pregnane glycosides, ptilosaponoside A (4) and ptilosaponoside B (5), were isolated from the marine sponge Ptilocaulis spiculifer collected in the Solomon Islands. The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.

Domaines: Biologie cellulaire

Marion Gabant, Isabelle Schmitz-Afonso, Jean-François Gallard, Jean-Louis Menou, Dominique Laurent, et al.. Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer.. Journal of Natural Products, 2009, 72 (4), pp.760-3. ⟨10.1021/np800758c⟩. ⟨hal-00385015⟩