Preparation of pH-sensitive particles by membrane contactor

Abstract : In this work, pH-sensitive particles are synthesized using a membrane contactor technique. The polymer (Eudragit® L100 or Eudragit® E100) is dissolved in water at a set pH and is then passed through the pores of a membrane into a continuous phase of a different pH. Contact with the continuous phase causes the pH-sensitive polymer to precipitate. The final particle size distribution (PSD) using this membrane contactor technique is compared to that of a similar batch process. The influence of the different parameters of the process (pressure, cross-flow velocity, concentration of polymer and temperature) on the PSD are studied. The results allow analysis of the different forces controlling the formation of droplets at the membrane pores.
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Article dans une revue
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Elsevier, 2008, 315, pp.13-22
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https://hal.archives-ouvertes.fr/hal-00358472
Contributeur : Nida Sheibat-Othman <>
Soumis le : mardi 3 février 2009 - 15:30:21
Dernière modification le : jeudi 19 avril 2018 - 14:34:08

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  • HAL Id : hal-00358472, version 1

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Nida Sheibat-Othman, Tim Burne, Catherine Charcosset, Hatem Fessi. Preparation of pH-sensitive particles by membrane contactor. Colloids and Surfaces A: Physicochemical and Engineering Aspects, Elsevier, 2008, 315, pp.13-22. 〈hal-00358472〉

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