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A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya.

Abstract : DNA topoisomerase IB (TopoIB) was thought for a long time to be a eukaryotic specific enzyme. A shorter version was then found in viruses and later on in several bacteria, but not in archaea. Here, we show that a eukaryotic-like TopoIB is present in the recently sequenced genomes of two archaea of the newly proposed phylum Thaumarchaeota. Phylogenetic analyses suggest that a TopoIB was present in the last common ancestor of Archaea and Eucarya. This finding indicates that the last common ancestor of Archaea and Eucarya may have harboured a DNA genome.
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https://hal.archives-ouvertes.fr/hal-00353347
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Submitted on : Thursday, February 26, 2009 - 7:36:31 PM
Last modification on : Monday, October 17, 2022 - 1:43:08 PM
Long-term archiving on: : Saturday, November 26, 2016 - 4:30:11 AM

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Céline Brochier-Armanet, Simonetta Gribaldo, Patrick Forterre. A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya.. Biol Direct, 2008, 3, pp.54. ⟨10.1186/1745-6150-3-54⟩. ⟨hal-00353347⟩

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