Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer-maleic anhydride-N-vinyl pyrrolidone terpolymers

Abstract : Oligocaprolactone macromonomers functionalized with vinyl ether have been synthesized by polymerization of ε-caprolactone in the presence of hydroxy ethyl or butyl vinyl ether and characterised by NMR and Maldi time-of-flight mass spectroscopy. These macromonomers have been copolymerized with maleic anhydride and N-vinyl pyrrolidone to give terpolymers, which have been used to obtain nanoparticles by the phase-separation-dialysis method. Previously dissolving indomethacin in the terpolymer solution allows one to encapsulate the drug inside the nanoparticles.
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Polymer International, Wiley, 2006, 55 (2), pp. 222-228. 〈10.1002/pi.1964〉
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https://hal.archives-ouvertes.fr/hal-00333644
Contributeur : Michel Levy <>
Soumis le : jeudi 23 octobre 2008 - 17:02:38
Dernière modification le : mardi 11 septembre 2018 - 10:57:40

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Cristina Iojoiu, David Cade, Hatem Fessi, Thierry Hamaide. Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer-maleic anhydride-N-vinyl pyrrolidone terpolymers. Polymer International, Wiley, 2006, 55 (2), pp. 222-228. 〈10.1002/pi.1964〉. 〈hal-00333644〉

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