Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer-maleic anhydride-N-vinyl pyrrolidone terpolymers

Cristina Iojoiu (1, 2, 3, 4) , David Cade (1) , Hatem Fessi (2) , Thierry Hamaide (1)

1 LCPP - Laboratoire de chimie et procédés de polymérisation
2 LAGEP - Laboratoire d'automatique et de génie des procédés
3 “Petru Poni” Institute of Macromolecular Chemistry
4 LEPMI - Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces

Oligocaprolactone macromonomers functionalized with vinyl ether have been synthesized by polymerization of ε-caprolactone in the presence of hydroxy ethyl or butyl vinyl ether and characterised by NMR and Maldi time-of-flight mass spectroscopy. These macromonomers have been copolymerized with maleic anhydride and N-vinyl pyrrolidone to give terpolymers, which have been used to obtain nanoparticles by the phase-separation-dialysis method. Previously dissolving indomethacin in the terpolymer solution allows one to encapsulate the drug inside the nanoparticles.

Mots clés: caprolactone vinyl ether macromonomer; copolymerization; terpolymers; nanoparticles; indomethacin encapsulation

Domaines: Matériaux

Cristina Iojoiu, David Cade, Hatem Fessi, Thierry Hamaide. Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer-maleic anhydride-N-vinyl pyrrolidone terpolymers. Polymer international, 2006, 55 (2), pp. 222-228. ⟨10.1002/pi.1964⟩. ⟨hal-00333644⟩