The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.

Edurne Berra (1) , Amandine Ginouvès (1) , Jacques Pouysségur (1)

1 IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

Domaines: Cancer; Biochimie, Biologie Moléculaire

Edurne Berra, Amandine Ginouvès, Jacques Pouysségur. The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.. EMBO Reports, 2006, 7 (1), pp.41-5. ⟨10.1038/sj.embor.7400598⟩. ⟨hal-00321549⟩