The CD95 receptor: apoptosis revisited.

Marcus E Peter (1) , Ralph C Budd (2) , Julie Desbarats (3) , Stephen M Hedrick (4) , Anne-Odile Hueber (5) , M Karen Newell (6) , Laurie B Owen (7) , Richard M Pope (8) , Juerg Tschopp (9) , Harald Wajant (10) , David Wallach (11) , Robert H Wiltrout (12) , Martin Zörnig (13) , David H Lynch (14)

1 Ben May Department for Cancer Research
2 Department of Medicine, Univ. Vermont
3 Department of Physiology [Montréal]
4 UC San Diego - University of California [San Diego]
5 IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer
6 Institute of Bioenergetics, Univ. Colorado
7 UC Riverside - University of California [Riverside]
8 Division of Rheumatology
9 Department of Biochemistry [Lausanne]
10 Department of Molecular Internal Medicine, Univ. Wuerzburg
11 Department of Biological Chemistry
12 Laboratory of Experimental Immunology
13 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus
14 Bainbridge Biopharma Consulting

CD95 is the quintessential death receptor and, when it is bound by ligand, cells undergo apoptosis. Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.

Domaines: Biologie du développement

Marcus E Peter, Ralph C Budd, Julie Desbarats, Stephen M Hedrick, Anne-Odile Hueber, et al.. The CD95 receptor: apoptosis revisited.. Cell, 2007, 129 (3), pp.447-50. ⟨10.1016/j.cell.2007.04.031⟩. ⟨hal-00318978⟩