Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method.

Sophie Limou (1, 2, 3) , Cédric Coulonges (3) , Mario Foglio (1) , Simon Heath (1) , Gora Diop (1, 3) , Sigrid Leclerc (2, 3) , Thomas Hirtzig (1) , Jean-Louis Spadoni (3) , Amu Therwath (4) , Gérard Lambeau (5) , Ivo Gut (1) , Jean-François Zagury (2, 3)

1 CNG - Centre National de Génotypage
2 IMRB - Institut Mondor de recherche biomédicale
3 Chaire de Bioinformatique
4 Laboratoire d'Oncologie Moléculaire
5 IPMC - Institut de pharmacologie moléculaire et cellulaire

Members of the secreted phospholipase A2 (PLA2) protein family can inhibit HIV-1 virus replication in vitro. To evaluate the impact of PLA2 gene polymorphisms on AIDS disease development, we studied 12 family members using SNPlextrade mark technology that permitted simultaneous typing of 70 tagging Single Nucleotide Polymorphisms (tagSNPs). The study utilized HIV-1 seropositive donors with slow progressor (n=168) or rapid progressor (n=54) status, plus 355 control subjects. All donors were Caucasian (total 577 individuals). Genetic associations yielded mainly 0.01

Domaines: Génétique

Sophie Limou, Cédric Coulonges, Mario Foglio, Simon Heath, Gora Diop, et al.. Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method.. Biomedecine & Pharmacotherapy, 2008, 62 (1), pp.31-40. ⟨10.1016/j.biopha.2007.11.001⟩. ⟨hal-00315368⟩