The atomic structure of the bluetongue virus core.

Jm Grimes (1) , Jn Burroughs (1) , P. Gouet (1) , Jm Diprose (1) , R. Malby (1) , Stéphan Zientara (1) , Pp Mertens (1) , Di Stuart (1)

1 IBCP - Institut de biologie et chimie des protéines [Lyon]

The structure of the core particle of bluetongue virus has been determined by X-ray crystallography at a resolution approaching 3.5 A. This transcriptionally active compartment, 700 A in diameter, represents the largest molecular structure determined in such detail. The atomic structure indicates how approximately 1,000 protein components self-assemble, using both the classical mechanism of quasi-equivalent contacts, which are achieved through triangulation, and a different method, which we term geometrical quasi-equivalence.The structure of the core particle of bluetongue virus has been determined by X-ray crystallography at a resolution approaching 3.5 A. This transcriptionally active compartment, 700 A in diameter, represents the largest molecular structure determined in such detail. The atomic structure indicates how approximately 1,000 protein components self-assemble, using both the classical mechanism of quasi-equivalent contacts, which are achieved through triangulation, and a different method, which we term geometrical quasi-equivalence.

Domaines: Biochimie, Biologie Moléculaire

Jm Grimes, Jn Burroughs, P. Gouet, Jm Diprose, R. Malby, et al.. The atomic structure of the bluetongue virus core.. Nature, 1998, 395, pp.470-478. ⟨10.1038/26694⟩. ⟨hal-00314291⟩