First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles

G. Cusati (1) , L. Djakovitch (1)

1 IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon

A simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. Under relatively standard reaction conditions (Pd-catalyst, K2CO3, dioxane, reflux), using only 1 mol % [Pd(NH3)4]/NaY as the catalyst, indoles substituted or not at position 2 gave up to 92% conversion (i.e., 85% isolated yield) towards the expected C3-arylated indole.

Mots clés: Indoles; Selective C3-arylation; Palladium; Heterogeneous catalysis; "Indoles"; "Selective C3-arylation"; "Palladium"; "Heterogeneous catalysis"

Domaines: Environnement et Société; Catalyse

G. Cusati, L. Djakovitch. First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles. Tetrahedron Letters, 2008, 49, pp.2499-2502. ⟨10.1016/j.tetlet.2008.02.130⟩. ⟨hal-00281238⟩