Towards better DNA chip hybridization using chaotic advection

Abstract : Numerical studies for two protocols of micromixing based on chaotic advection to improve DNA chip hybridization are presented. The first protocol uses syringes; the other one, pumps. For both protocols, numerical Poincaré sections and Lyapunov exponents of the three-dimensional, time-periodic flow are investigated as functions of the period. Model experiments also confirm numerical results. Homogeneity of the dispersion of particles inside the chamber is of primary importance to achieve best chip reliability: although global chaos was obtained for both protocols, we find that the one employing the pumps is more likely to achieve better and more rapid hybridization.
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Florence Raynal, Aurélien Beuf, Frédéric Plaza, Julian F. Scott, Philippe Carrière, et al.. Towards better DNA chip hybridization using chaotic advection. Physics of Fluids, American Institute of Physics, 2007, 19, pp.017112. ⟨10.1063/1.2431322⟩. ⟨hal-00272171⟩

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