Increased Dosage of DYRK1A and Brain Volumetric Alterations in a YAC Model of Partial Trisomy 21.

Catherine Sebrié (1) , Caroline Chabert , Aurélie Ledru , Fayçal Guedj , Chrystelle Po (1) , Desmond J Smith , Edward Rubin , Isabelle Rivals , Jean-Claude Beloeil (1) , Brigitte Gillet (1) , Jean-Maurice Delabar

1 ICSN - Institut de Chimie des Substances Naturelles

A yeast artificial chromosome (YAC) transgenic murine model of partial trisomy 21 overexpressing five human genes-including DYRK1A, which encodes a serine threonine kinase involved in cell cycle control-has been shown to present an increase in brain weight. We analyzed this new phenotype by measuring total and regional brain volumes at different ages, using a 7 Tesla magnetic resonance imaging volumetric approach. Volumetric measurements showed a total volume increase of 13.6% in adult mice. Changes in brain morphogenesis were already visible at a very early postnatal stage (postnatal days 2-7). Region-specific changes were characterized from postnatal day 15 to 5 months. These results, made it possible to define region-specific effects of DYRK1A overexpression, with the strongest increase seen in the thalamus-hypothalamus area (24%). Anat Rec, 291:254-262, 2008. (c) 2008 Wiley-Liss, Inc.

Domaines: Biologie cellulaire

Catherine Sebrié, Caroline Chabert, Aurélie Ledru, Fayçal Guedj, Chrystelle Po, et al.. Increased Dosage of DYRK1A and Brain Volumetric Alterations in a YAC Model of Partial Trisomy 21.. The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology, 2008, 291 (3), pp.254-62. ⟨10.1002/ar.20640⟩. ⟨hal-00265614⟩