Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

Pascale Joseph (1) , Marie-Rose Abdo (2) , Rose-Anne Boigegrain (1) , Jean-Louis Montero (2) , Jean-Yves Winum (2) , Stephan Köhler (1)

1 IRIM - Institut de Recherche en Infectiologie de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity.

Domaines: Microbiologie et Parasitologie

Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain, Jean-Louis Montero, Jean-Yves Winum, et al.. Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.. Antimicrobial Agents and Chemotherapy, 2007, 51 (10), pp.3752-5. ⟨10.1128/AAC.00572-07⟩. ⟨hal-00258959⟩