Exploring functional genomics for drug target and therapeutics discovery in Plasmodia.

L. Birkholtz (1, 2) , A. C. van Brummelen (1) , K. Clark (1) , J. Niemand (1) , E. Maréchal (3) , M. Llinás (4) , A. I. Louw (1, 2)

1 Department of Biochemistry, Genetics and Microbiology [Pretoria]
2 African Centre for Gene Technologies
3 LPCV - Laboratoire de physiologie cellulaire végétale
4 Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics

Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.

Mots clés: Human parasite; malaria; Apicomplexa; Plasmodium; functional genomics; transcriptome; proteome; interactome; drug target; therapeutics

Domaines: Biochimie, Biologie Moléculaire

L. Birkholtz, A. C. van Brummelen, K. Clark, J. Niemand, E. Maréchal, et al.. Exploring functional genomics for drug target and therapeutics discovery in Plasmodia.. Acta Tropica, 2008, 105 (2), pp.113-23. ⟨10.1016/j.actatropica.2007.10.013⟩. ⟨hal-00250161⟩