The receptor of the type I interferon family.

G. Uzé (1, 2) , G. Schreiber (3) , J. Piehler (4) , S. Pellegrini (5)

1 DIMNP - Dynamique des interactions membranaires normales et pathologiques
2 DAA - Défenses antivirales et antitumorales
3 Department of Biological Chemistry
4 Institute of Biochemistry
5 Signalisation des Cytokines - Cytokine Signaling

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

Domaines: Biochimie, Biologie Moléculaire

G. Uzé, G. Schreiber, J. Piehler, S. Pellegrini. The receptor of the type I interferon family.. Current Topics in Microbiology and Immunology, 2007, 316, pp.71-95. ⟨10.1007/978-3-540-71329-6_5⟩. ⟨hal-00202867⟩