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The receptor of the type I interferon family.

Abstract : All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.
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https://hal.archives-ouvertes.fr/hal-00202867
Contributor : Annie Bosch-Savary Connect in order to contact the contributor
Submitted on : Tuesday, January 8, 2008 - 12:36:36 PM
Last modification on : Thursday, April 7, 2022 - 10:10:08 AM

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G. Uzé, G. Schreiber, J. Piehler, S. Pellegrini. The receptor of the type I interferon family.. Current Topics in Microbiology and Immunology, Springer Verlag (Germany), 2007, 316, pp.71-95. ⟨10.1007/978-3-540-71329-6_5⟩. ⟨hal-00202867⟩

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